然而,一些患者即使 较高
,也不会表现出 引起的 。值得注意的是,在我们的研究中,具有突变的 或 患者往往具有较高的 ,但根据时序检验,这些人对抗 的反应较差。此外,单变量分析显示, 往往与 和 中免疫治疗反应不佳相关( > )。调整后突变、年龄和性别, 在四种癌症类型中的临床获益趋势相似。这些发现进一步表明 不足以预测免疫治疗反应的临床获益。需要识别生物标志物作为现有 方法的补充。 最近的研究表明,免疫细胞浸润是 治疗的关键因 素 。我们的研究表明,表达与许多癌症类型的免疫浸润相关。苗等人。据报道,携带突变的肿瘤显示出比具有完整的肿瘤哥斯达黎加电话号码表更低的免疫抑制配体表达 。卡迈勒等人。据报道, 的失活突变与 中衰老富集度的降低独立相关,而高肿瘤衰老活性与检查点阻断治疗的临床获益相关()。这些机制可能导致免疫治疗患者的免疫治疗临床结果不佳。 据报道,突变型 患者具有高血管生成能力,并且对抗血管生成治疗反应良好 。美国食品和药物管理局 已批 准抗血管生成药物,如贝伐单抗、索拉非尼和舒尼替尼,用于 治疗多种实体瘤 。
https://lh4.googleusercontent.com/gz-TMfq7bMAMLvtfr2EJwgnBiJdyaGRajInA4WFxGy-rgUrdHaqXRCBn2k1x7na97SVVpuI9s1i59MCxWF5cJDWP01HZVy4NsD29S3Nukg3fbZhEHwYChOO_xh8UxwR_S6CHsPsgggL9zwyuYm_6C-g
抗血管生成抑制剂被认为不仅在肿瘤血管生成中发挥重要作用,而且在促进免疫细胞浸润方面也发挥着重要作用 。需要进一步研究来确定患有 或 或其他癌症的突变患者是否可以从抗血管生成治疗中获益。 这项研究受到样本量和患者病史的限制。需要进一步的研究来验证我们的发现。我们的结果可能为基于突变的研究和前瞻性临床试验提供动力。 致谢其他部分 资金:无。 脚注其他部分 报告清单:作者已完成 报告清单。
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